In vitro Synergistic effect of Cassia fistula leaves extracts with Fluconazole against clinical isolates of Candida albicans
نویسنده
چکیده
The aim of the study was to evaluate the synergistic antifungal action of crude DMSO (Di methyl sulphoxide) & Petroleum ether leaves extract of Cassia fistula in conjunction with fluconazole against candidial species isolated from Candidasis patients. Correlation was observed between the leaves & fluconazole, therefore it was also found that the antifungal action of Cassia fistula leaves extract was enhanced (up to 3 times) in combination with fluconazole on fluconazole resistance Candida albicans strains isolated from patients with Candidiasis. The plant appears to play an important role in overcoming the azole resistant of Candidial strains. IC50 was determined by agar well diffusion and broth dilution method in the presence of fluconazole and leaves extracts of Cassia fistula in different solvents. Synergistic behavior of leaves extracts in Pet. Ether and DMSO extract of Cassia fistula with fluconazole was checked by broth dilution method.
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